| Date | Teams | Spread | Money | Total |
|---|---|---|---|---|
| Friday, Apr. 19, 08:20 pm |
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| Milwaukee Brewers at | (-1.5) 143 | -115 | (O: 7) -118 | |
| St. Louis Cardinals | (+1.5) -163 | +105 | (U: 7) -102 | |
| Friday, Apr. 19, 10:15 pm |
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| New York Mets at | (+1.5) -121 | +172 | (O: 8.5) -107 | |
| Los Angeles Dodgers | (-1.5) +101 | -188 | (U: 8.5) -113 | |
| Friday, Apr. 19, 10:20 pm |
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| Arizona Diamondbacks at | (+1.5) -195 | +115 | (O: 7.5) +104 | |
| San Francisco Giants | (-1.5) +170 | -125 | (U: 7.5) -124 | |
| Friday, Apr. 19, 07:15 pm |
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| Oakland Athletics at | (+1.5) -146 | +146 | (O: 8) -107 | |
| Cleveland Guardians | (-1.5) +126 | -159 | (U: 8) -113 | |
| Friday, Apr. 19, 07:45 pm |
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| Baltimore Orioles at | (-1.5) 117 | -130 | (O: 9) -112 | |
| Kansas City Royals | (+1.5) -137 | +120 | (U: 9) -108 | |
| Friday, Apr. 19, 08:15 pm |
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| Detroit Tigers at | (+1.5) -163 | +138 | (O: 7) +101 | |
| Minnesota Twins | (-1.5) +143 | -150 | (U: 7) -121 | |
| Friday, Apr. 19, 07:25 pm |
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| Texas Rangers at | (+1.5) -116 | +183 | (O: 9.5) +101 | |
| Atlanta Braves | (-1.5) -104 | -202 | (U: 9.5) -121 | |
| Friday, Apr. 19, 09:45 pm |
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| Toronto Blue Jays at | (+1.5) -215 | -106 | (O: 8.5) +104 | |
| San Diego Padres | (-1.5) +185 | -104 | (U: 8.5) -124 | |
| Saturday, Apr. 20, 02:20 pm |
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| Milwaukee Brewers at | +109 | (O: 8) -125 | ||
| St. Louis Cardinals | -119 | (U: 8) +105 | ||
| Saturday, Apr. 20, 04:10 pm |
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| Arizona Diamondbacks at | -120 | (O: 8) +100 | ||
| San Francisco Giants | +110 | (U: 8) -120 | ||
| Saturday, Apr. 20, 01:10 pm |
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| Tampa Bay Rays at | +120 | (O: 8.5) +105 | ||
| New York Yankees | -130 | (U: 8.5) -125 | ||
| Saturday, Apr. 20, 02:15 pm |
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| Detroit Tigers at | +118 | (O: 8) -104 | ||
| Minnesota Twins | -128 | (U: 8) -116 | ||
| Saturday, Apr. 20, 06:15 pm |
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| Oakland Athletics at | +142 | (O: 8.5) +110 | ||
| Cleveland Guardians | -155 | (U: 8.5) -130 | ||
| Saturday, Apr. 20, 07:15 pm |
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| Baltimore Orioles at | -124 | (O: 8) -104 | ||
| Kansas City Royals | +114 | (U: 8) -116 | ||
| Saturday, Apr. 20, 04:10 pm |
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| Boston Red Sox at | +110 | (O: 8) -103 | ||
| Pittsburgh Pirates | -120 | (U: 8) -117 | ||
| Saturday, Apr. 20, 04:10 pm |
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| Houston Astros at | -167 | (O: 8.5) -125 | ||
| Washington Nationals | +153 | (U: 8.5) +105 | ||
| Saturday, Apr. 20, 06:10 pm |
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| Chicago White Sox at | +242 | (O: 7.5) -125 | ||
| Philadelphia Phillies | -275 | (U: 7.5) +105 | ||
| Saturday, Apr. 20, 07:25 pm |
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| Texas Rangers at | +141 | (O: 9.5) -105 | ||
| Atlanta Braves | -154 | (U: 9.5) -115 |