| Date | Teams | Spread | Money | Total |
|---|---|---|---|---|
| Wednesday, Aug. 17, 04:15 pm |
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| San Diego Padres at | (-1.5) 113 | -153 | (O: 7) -118 | |
| Miami Marlins | (+1.5) -133 | +141 | (U: 7) -102 | |
| Wednesday, Aug. 17, 07:25 pm |
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| New York Mets at | (-1.5) 122 | -141 | (O: 7.5) -110 | |
| Atlanta Braves | (+1.5) -142 | +130 | (U: 7.5) -110 | |
| Wednesday, Aug. 17, 07:50 pm |
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| Colorado Rockies at | (+1.5) -128 | +180 | (O: 7) -110 | |
| St. Louis Cardinals | (-1.5) +108 | -196 | (U: 7) -110 | |
| Wednesday, Aug. 17, 08:15 pm |
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| Los Angeles Dodgers at | (-1.5) -105 | -172 | (O: 8) -115 | |
| Milwaukee Brewers | (+1.5) -115 | +158 | (U: 8) -105 | |
| Wednesday, Aug. 17, 09:50 pm |
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| Arizona Diamondbacks at | (+1.5) -118 | +190 | (O: 7) -128 | |
| San Francisco Giants | (-1.5) -102 | -208 | (U: 7) +108 | |
| Wednesday, Aug. 17, 03:12 pm |
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| Baltimore Orioles at | (+1.5) -140 | +149 | (O: 8.5) -116 | |
| Toronto Blue Jays | (-1.5) +120 | -162 | (U: 8.5) -104 | |
| Wednesday, Aug. 17, 04:12 pm |
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| Seattle Mariners at | (-1.5) -118 | -189 | (O: 8.5) -108 | |
| Los Angeles Angels | (+1.5) -102 | +174 | (U: 8.5) -112 | |
| Wednesday, Aug. 17, 07:10 pm |
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| Tampa Bay Rays at | (+1.5) -170 | +122 | (O: 8.5) -114 | |
| New York Yankees | (-1.5) +150 | -132 | (U: 8.5) -106 | |
| Wednesday, Aug. 17, 07:15 pm |
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| Detroit Tigers at | (+1.5) -115 | +184 | (O: 7) -130 | |
| Cleveland Guardians | (-1.5) -105 | -201 | (U: 7) +110 | |
| Wednesday, Aug. 17, 08:10 pm |
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| Oakland Athletics at | (+1.5) -150 | +143 | (O: 9) -103 | |
| Texas Rangers | (-1.5) +130 | -155 | (U: 9) -117 | |
| Wednesday, Aug. 17, 08:15 pm |
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| Houston Astros at | (-1.5) 110 | -147 | (O: 8) -110 | |
| Chicago White Sox | (+1.5) -130 | +136 | (U: 8) -110 | |
| Wednesday, Aug. 17, 07:10 pm |
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| Boston Red Sox at | (-1.5) 105 | -149 | (O: 8) -113 | |
| Pittsburgh Pirates | (+1.5) -125 | +138 | (U: 8) -107 |